Integrated taxonomic approaches to seven species of capillariid nematodes (Nematoda: Trichocephalida: Trichinelloidea) in poultry from Japan and Indonesia, with special reference to their 18S rDNA phylogenetic relationships
The causal relationship between severe allergic conditions and successful
pregnancy remains unclear. We aimed to evaluate reproductive performance in an
experimental mouse model of atopic disease (AD), and the appearance of uterine natural
killer (uNK) cells that have crucial roles in placental formation was examined. In the
NC/Nga pregnant mice with moderate skin allergic lesions and an 8.6-fold elevation of
plasma IgE, significant differences were not detected in the reproductive indices of the
number of normal fetuses, abortion rate and placental size. There were few uNK cells in
the placenta of AD mice, and they showed a significant decrease regarding the immature
subtype as compared with controls. These findings revealed that AD disturbs uNK cell
differentiation and provides disadvantageous effects on placental formation, although it
does not arrest the pregnancy process. It may be possible that specific immunological
conditions behind AD operate favorably to recover the reproductive performance.
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