Recent studies have suggested that the calcium antagonists have an antiatherogenic antioxidant property.The effects of the calcium antagonists on reactive oxygen species (ROS)-related enzymes, however, remain unknown. We hypothesized that the calcium antagonists inhibit oxidative stress in the hearts of strokeprone spontaneously hypertensive rats (SHRSP) through the ROS-scavenging enzymes known as superoxide dismutases (SODs). Male 12-week-old Wister-Kyoto rats (WKY) and SHRSP were used for the study.

. Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-␥, and aortic stiffness in hypercholesterolemia.

Although angiotensin II type 1 (AT1) receptor antagonists and angiotensin-converting enzyme (ACE) inhib

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To clarify the precise mechanisms involved in the reduced coronary flow reserve in hypertension, we com- is a vasoconstrictor and trophic factor that mediates contractile and proliferative actions in hypertension mainly by stimulating the Ang II type 1 (AT1) receptor (4, 5). Ang II is also important for vascular remodeling, since inhibition of the renin-angiotensin system with angiotensin-converting enzyme (ACE) inhibitors or AT1 receptor antagonists corrects vascular structure and endothelial dysfunction in small arteries, including endothelial dysfunction of the coronary vasculature, impairment of coronary hemodynamics, LV hypertrophy, and contractile dysfunction, thereby exacerbating myo-