Exercise is an important aspect of diabetes treatment because it improves insulin sensitivity, increases muscle mass, and assists in weight control 1,2) . However, diet and exercise therapies for lifestyle-related diseases, such as obesity, diabetes, hypertension, and dyslipidemia do not necessarily lower blood pressure (BP). In addition, The Trial of Preventing Hypertension (TROPHY) study 3) for participants with prehypertension reported that life-style modifications alone, including diet and exercise regimens, coincided with a 40.4% and 63.0% incidence of hypertension after 2 and 4 years, respectively. Furthermore, an exercise regimen for an essential hypertension model, spontaneously hypertensive rat (SHR) 4) , produced cardiac hypertrophy, cardiomyocyte fibrosis, and renal hypertrophy accompanied by enlargement of glomerular and mesangial areas of the kidneys. Additionally, this regimen was associated with increased BP. Previous studies 1,5,6) reported that the diet regimen for Otsuka Long-Evans Tokushima fatty (OLETF) rats, a rat model of type-2 diabetes 7) , showed neither increase in urinary excretion of al-
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.