Background: Nocistatin (NST) is involved in pain transmission. Results: 4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) is purified by using NST-conjugated beads. The inhibition of tactile allodynia by NST is abolished in NIPSNAP1-deficient mice. Conclusion: NIPSNAP1 interacts with NST and mediates pain modulation by NST. Significance: These results may provide a novel therapeutic target for pathological pain.
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