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In a previous paper, the only relationship identified between host factors was that between age and performancc status3). Few studies have been made on the prognostic factors of survival in oral squamous cell carcinoma (O-SCC) patients with Stage I and ll2'5). Moreover, the factors predictive of prognosis have also not been well described. This study evaluated the ability of certain clinical and pathologic parameters to make an accurate prognosi$ of Stage I and ll O-SCC patients. Patients and Methods t A total of 120 previously untreated patients with Stage I and I O-SCC, treated between 1978 and 1995, were retrospectively studied.

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Tumor markers, which are tumor-mediated substances, are not specific substances directly produced by tumor tissueD. The use of tumor markers has been accepted as a valuable tool for diagnosis, prognosis and treatment monitoringU'6), The tumor markers that have been used in patients with oral squamous cell carcinoma (O-SCC) include carcineembryonic antigen (CEA)7'8), squamous cell carcinoma-antigen (SCCA)T'9), and immunosuppressive acidic protein (IAP)T). All of these markers have very low sensitivity in O-SCC and are not useful for clinical purposes.

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