No abstract
LE JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUESSuppl. 2 -S9 in a non-invasive and objective manner. Methods: SsVEPs were obtained in ten children with OPGs and 42 controls ages 3 to 21. The stimuli consisted of two circular dartboard patterns stimulating fovea and peripheral zones at two flickering frequencies, so that central and peripheral visual fields could be assessed simultaneously. The test consisted of eight stimuli presentations of 10 seconds. Results: Results indicate significantly lower ssVEP amplitudes in children with OPGs (M = 2.52, 95% CI [1.13, 3.92]) compared to controls (M = 13.26, 95% CI [8.85, 17.67]) in the central visual field (p = .021). However, no between group differences were detected in the peripheral field (p >.05). There were no significant differences between age groups (p > 0.05). Conclusions: This objective, affordable, and non-invasive method appears to be effective in detecting central visual field deficits in children with OPGs rapidly and consistently. A.03Analyses of surgical and MRI factors associated with cerebellar mutism Background: The surgical risk factors and neuro-imaging characteristics associated with cerebellar mutism (CM) remain unclear and require further investigation. We aimed to examine surgical and MRI findings associated with CM in children following posterior fossa tumor resection. Methods: Using our data registry, we retrospectively collected data from pediatric patients who acquired CM and were matched based on age and pathology type with patients not acquiring CM after posterior fossa surgery. The strength of association between surgical and MRI variables and CM were examined using odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Results: A total of 22 patients were included. Medulloblastoma was the most common pathology among CM patients (91%). Tumor attachment to the floor of the fourth ventricle (OR, 6; 95% CI, 0.7-276), calcification/hemosiderin deposition (OR 7; 95% CI 0.9-315.5), and post-operative peri-ventricular ischemia on MRI (OR, 5; 95% CI, 0.5-236.5) were found to have the highest association with CM. Conclusions: Our results may suggest that tumor attachment to the floor of the fourth ventricle, pathological calcification, and postoperative ischemia are relatively more prevalent in patients with CM. Collectively, our work calls for a larger multi-institutional study of CM patients to further investigate the determinants and management of CM to potentially minimize its development and predict onset. Background: Oligodendroglioma (ODG), a molecularly defined subtype of glioma, is a treatment responsive, slow growing tumour strongly associated with IDH mutation and 1p19q co-deletion. Mutations in Capicua (CIC), located on chromosome 19q, have been found in up to 70% of IDH mutated, 1p19q co-deleted ODGs; suggesting that loss or altered function of CIC may be crucially associated with ODG's unique biology. CIC and ATXN1L have previously been implicated in neurodegeneration, however, this interaction has not been studied in ca...
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