Tne purpose of the present experiment was to examine the changes of physiological values possibly produced by the medication of a few of agricultural chemicals such as Diethyl Pnitrophenyl monothiophosphate (Parathion) and 1, 2 dicarboethoxyethyl dithiophosphate (Marathion) and make a detailed analysis of the changes from the view point of polygraphy in growing chicks. The results obtained were as follows :(1) Principal symptoms appeared in Parathion and/or Marathion poisoning in chicks presented a similarity to those observed in adult fowls and mammals medicated with them. Urination, lacrimation, salivation, piloerection and defecation etc. were usualy detected and muscular tremor was also frequently recognized. The vigorous difficulty of breathing and convulsion produced by injection of a large quantity of the drugs were always followed by death. The toxic potency of Parathion was presumed to be about 10 times stronger than that of Marathion.(2) The injection of Parathion into the pectoral muscle produced a prompt decrease of the heart beat rate and respiration frequency and a sudden decline of blood pressure. In this case, the death occured usually in few minutes after medication, despite quantity of the chemicals injected being distributed over a wide range of 15 mg/kg to 60 mg/kg.(3) The drug effect was influenced by density of the solution injected. An adequate dose for observing the typical phenomena in phosphate poisoning was 720 mg/kg in Marathion and 60 mg/kg in Parathion, by which the chicks could be kept alive long enough to the observation time of about 60 minutes.(4) The changes in physiological measures in case of the poisoning by organic phosphate medication followed after the above-mentioned clinical or external phenomena. A prompt decrease of the heart beat and a rapid decline of the blood pressure appeared almost simultaneously. An acceleration of respiratory movement gave rise immediately to occure before the death and its abrupt cease accompanying with vigorous convulsion.(5) It seems that Parathion acts further stronger to 4 weeks old chicks than 6 or 8 weeks old chicks from the vieow point of length of their living time.Ja p. J. Zootech. Sci., 37, (3). 99 1966. 3.
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