We performed single nucleotide polymorphism (SNP) array analysis of 35 newly diagnosed symptomatic multiple myeloma (MM) patients who received bortezomib-melphalan-prednisone (VMP) to identify collaborating genetic events that could predict the outcome of treatment. A total of 340 copy number variations (CNVs) were identified, with the most frequently identified CNVs being gains on 1q, 19p, 9q, 3q, 9p, 15q, 19q, 5q, 11q, 5p, and 7q and losses on 1p, X, 13q, 14q, and 6q. The number and proportion of detected abnormalities by SNP array were associated with presence of cytogenetic abnormalities and complex karyotype. Moreover, increasing genomic complexity as ascertained by SNP arrays correlated with outcome of the VMP treatment. The frequency of CNVs was significantly different according to achievement of very good partial response (VGPR) to VMP treatment (
The aim of this study was to define the location of the accessory infraorbital foramen (AIOF) with reference to accessible external landmarks in order to facilitate orbital and oculoplastic surgical procedures in the maxillofacial region. Forty-four hemifaces from 25 cadavers were dissected. The lateral canthus, subnasal point, and lacrimal caruncle were used as anatomic reference points. The AIOF was observed in 8 of the 44 hemifaces (18.2%) and was situated at a mean distance of 7.2 mm superomedial to the IOF. The horizontal distance from the lacrimal caruncle to the AIOF was 0.3 mm. In all cases the AIOF was situated at a point that was no more than 8 mm from the intersection point of a vertical line passing through the lacrimal caruncle and an oblique line joining the lateral canthus and the subnasal point. Surgeons anesthetizing or performing surgical procedures in the maxillofacial region should be aware of the frequency of the AIOF (18.2%) and its location (on the superomedial side of the IOF). We propose that injecting at the intersection point of a vertical line passing through the lacrimal caruncle and an oblique line joining the lateral canthus and the subnasal point would successfully block the accessory branch of the infraorbital nerve. Likewise, surgeons operating in this region should be aware of the location of the AIOF in order to avoid inadvertent iatrogenic injury to a duplicated infraorbital nerve.
The objective of this study was to investigate the change in near visual function after the administration of oral silodosin to patients with lower urinary tract symptom (LUTS).Methods: This prospective study included treatment naï ve patients who were scheduled to start treatment with silodosin for LUTS. A comprehensive ophthalmological evaluation including the near vision and the automated pupillometry was performed at baseline and after 3 months of silodosin treatment. For subjective assessment of near visual ability and satisfaction, a Near Activity Visual Questionnaire-10 (NAVQ-10) was also used at the same time (higher scores indicating worse quality).Results: Of 23 patients enrolled in this study, 15 continued with silodosin (8 mg once daily) treatment for 3 months and completed a follow-up evaluation. The mean age of participants was 60.4±8.4 years. Distant visual acuity and spherical error were unchanged after silodosin treatment. However, near vision acuity (logMAR) was improved after treatment (
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