Hepatocellular carcinoma (HCC) is the most common primary liver cancer, ranking the fourth highest mortality rate among all cancers [1,2].Although there has been some progress in the treatment of liver cancer, the metastasis and recurrence rates of liver cancer patients is high, leading to low survival rate and poor prognosis [3]. Therefore, it is necessary to study the pathogenesis of HCC and explore new therapeutic targets.Circular RNAs (CircRNAs) are one of the non-coding RNAs formed by covalently linking the 3' and 5' ends, which can regulate cancer
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