Purpose To fabricate high performance parts, this paper aims to systematically study the pores characteristics and their formation mechanisms in selective laser melting (SLM) AlSi10Mg. Design/methodology/approach Cubes of 10 × 10 × 5 mm were manufactured in different laser power, scan speed and scan space. Optical microscope (OM) and scanning electron microscopes (SEM) were used to observe morphology of pores. Findings Round or irregular pores were found in SLMed AlSi10Mg parts. All the round pores have smooth inner walls and locate in the melt pool. The formation mechanisms of the round pores are contributed to the evaporation of elements in the melt pool, H2O, high laser energy input and hollow powder. Irregular pores have rough inner walls. Big scan space, unevenness of the upper surface, large layer thickness, spatter and oxide are the main reasons of generating irregular pores which outside the melt pool. Instability of keyhole leads to the irregular pores locate in the bottom of keyhole mode melt pool. Originality/value Relationship between pores and melt pool were studied systematically for the first time. Researches of pores characteristics and their formation mechanisms in SLMed AlSi10Mg would be a valuable reference for researchers to obtain an important insight into and control the defect in SLMed Al alloy.

Hypoxia-induced pulmonary arterial hypertension (HPAH) is due to hypoxia caused by vascular endothelial cell remolding and damage. Previous studies have suggested that CX3CL1 plays an important role in HPAH which is affected by oxidative stress. Ca2+ channel activation correlated with increasing NF-κB levels induced by ROS. Tanreqing injection (TRQ) is a traditional Chinese medicine (TCM) for acute upper respiratory tract infection and acute pneumonia. In the present study, we explored the effect of TRQ on human pulmonary artery smooth muscle cells (HPASMCs) undergoing hypoxia and feasible molecular mechanisms involved in. Cell proliferation was assayed using CCK8 kits. Immunofluorescence and western blotting along with ELISA assay were performed to investigate the effect of TRQ on hypoxia-induced ROS, Ca2+, hydroxyl free radicals, and the expression of Ca2+ channel protein TRPC1, CX3CR1, HIF-1α, NF-κBp65, and p-NF-κBp65 in HPASMCs. Human CX3CL1 and the inhibitor of TRPC1 as SKF96365 were used for further investigation. TRQ inhibited hypoxia-induced increasing cell adhesion, ROS, Ca2+, hydroxyl free radicals, CX3CR1, HIF-1α, NF-κBp65 activation, and even on TRPC1 expression in HPASMC which tended to be attenuated even reversed by CX3CL1. Our results suggested that TRQ might help to attenuate remodeling of HPASMC through inhibiting the ROS and TRPC1/CX3CL1 signaling pathway.

The effect of line energy density (LED) and wall thickness on the top surface quality of AlSi10Mg sample fabricated by selective laser melting (SLM) has been investigated in this paper. It is observed that the surface morphology has great evolution which the molten track turns to regular and then to irregular with the increase in LED. The line roughness (Ra) and peak height (Rz) decrease first and then increase as the LED increases. The optimal LED for low Ra/Rz increases from 0.1389 J/mm to 0.30 J/mm with the wall thickness increases from 0.1 mm to 2 mm. This work can provide a guide of manufacturing complexy geometrical thin-walled parts with a fine top surface quality.