Background Mature bone marrow T lymphocytes and NK may have a special relevance in the control of the malignant growth. Objective We aimed to assess the percentage of the residual BM T-cells, (T-helper –T-cytotoxic- NKT) and the NK cells of childhood precursor B-lymphoblastic leukemia (B-ALL) as an indicator of innate and adaptive immunity in these patients. Subjects and Methods This study was conducted on 40 B-ALL patients, and 40 apparently healthy matched children served as a control group. The flow cytometry was used to assess the percentage of the residual BM T-cells (T-helper, T-cytotoxic and NKT), and the NK cells. Results Compared with the control group, the percentage of the residual BM T-cells, its subtypes (T-helper, T-cytotoxic), and NKT cells in addition to the NK cells was significantly decreased in Group IA, and Group IB, but there was no significant difference between Group IA and Group IB in all studied parameters. In terms of the CD4/CD8 ratio, there was a significant increase in Group IA as compared to the control group (P < 0.026), but there were no significant statistical differences in CD4/CD8 ratio between Groups IB, and the control. Likewise, in CD4/CD8 ratio between groups IA, and Groups IB (P > 0.05). The percentage of NK, and NKT cells shows a significant increase in Hepatomegaly and Splenomegaly, as compared to non-Hepatomegaly and non-Splenomegaly patients of Groups IB (P < 0.05). However, there was a significant increase in statistical differences in the percentage of NKT cell between non-Splenomegaly, as compared to Splenomegaly patients of Group IA (P < 0.05). Additionally, there is a negative correlation between B.M Blast% to CD4/CD8 ratio and NK%, but there is no significant correlation between B.M Blast% to NK T% in the group 1 A.
Background: Pneumonia represents a significant public health problem in the whole world, and it is one of the leading causes of morbidity and mortality among children. Disease severity and clinical outcome prediction are required in pneumonia to manage health resources and give effective treatment options. Ischemia-modified albumin (IMA) is a marker of the recently used oxidant-antioxidant mechanism and has been found toin crease in many inflammatory conditions. Procalcitonin (PCT) is released as a part of the pro-inflammatory response of the innate immune system from parenchymal cells reaching detectable levels within 4 h after endotoxin stimulation. Objectives: This study examined IMA and PCT levels in patients with pneumonia, in comparison with healthy controls and their possible association with disease severity and outcome. Methods: A total of 90 cases of pneumonia and 90 controls were included in this cohort observational study, and severity grading was performed according to pediatric respiratory severity score (PRESS). Serum IMA and PCT were evaluated in all study subjects. Results: In pneumonia, IMA levels were significantly elevated as compared with controls, and it was elevated in died patients compared to those who were discharged.IMA showed a significant positive correlation with PRESS.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.