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BACKGROUNDBursitis is described as inflammation of a bursa. Bursitis may result from several causes like 1,2 direct injury or trauma, prolonged pressure, overuse or strenuous activity, crystal-induced arthropathy, inflammatory arthritis and infection (septic bursitis). The majority of cases of septic bursitis are due to bacterial pathogens. More recently, reports have appeared in the literature of chronic infectious bursitis caused by fungi and occurring in both immunocompromised and healthy immunocompetent individuals. 3
Lithium has been used frequently in the management of Affective disorders for six decades and known to cause dermatological adverse events in the form of Acne, exacerbation of Psoriasis etc. Here we report another dermatological manifestation of Lithium therapy, induction of Dariers disease. Though there are reports of Lithium exacerbating the lesions of Dariers disease, it is rare that the Lithium therapy itself precipitating the emergence of the lesions.
Giant cell lesions of bone include a relatively large group of biologically and morphologically diverse bone lesions which shows presence of numerous multinucleate osteoclast like giant cells. Recently, p63 has been found to be a sensitive marker in the diagnosis of giant cell tumor. The aim of this case series is to assess the role of p63 in diagnostically difficult giant cell lesions of bone. This study has been conducted in a tertiary care center in North Kerala. Giant cell rich lesions of bone in hematoxylin and eosin staining, in which an accurate diagnosis is not possible with the available clinical and radiological data are included in this study. The tissue was stained with hematoxylin and eosin and immunohistochemical staining with p63 was done. Though the specificity of the marker was found to be less, it was concluded that, p63 can be used as an ancillary aid along with histomorphological and radiological data in arriving at a diagnosis.
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