Aim:
In the present study, the phytochemical screening was carried out with the methanolic
extract of Ficus auriculata Lour figs.
Background:
Naturally occurring phytoconstituents have long been utilised to treat illnesses, and
these substances have provided natural product chemists with a source of structural diversity. Natural
products are usually cited as a rich source of chemical variations in the search for new pharmacological
leads or compounds.
Objective:
The investigation of chemical constituents of the methanolic extract resulted in the identification
of a novel phytoconstituent, namely, 10-methyl-9,10-dihydroacridin-1-ol (A), with acridine
as a basic nucleus.
Methods:
The structure of the compound was established by spectroscopic analysis using FT-IR,
1HNMR, 13CNMR, and MS.
Results:
The purity of the compound was confirmed by RP-HPLC. Forty-eight known and reported
compounds were also identified, along with novel compound-A. Among the forty-eight known
compounds, forty-five compounds were first reported in Ficus auriculata Lour methanolic extract
and the remaining three compounds (Campesterol, Stigmasterol, and Lanosterol) in the Ficus family.
Based on the previous studies, acridine moieties have a significant role in biological activities.
Conclusion:
The compound-A, 10-methyl-9,10-dihydroacridin-1-ol was successfully isolated from
the methanolic extract of the Ficus auriculata Lour fig. The structure of the novel compound was
established by various spectral data obtained from FT-IR, 1HNMR, 13CNMR, and LC-MS/MS.
Others:
The isolated novel acridine derivative may be helpful for the development of lead moieties
which may have various applications.
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