AD was associated with both malnutrition and higher levels of Hcy. Betaine could restore Hcy expression to normal level in AD patient, which might ameliorate memory deficits.
High serum uric acid (sUA) has been reported to be a risk factor for hypertension however, whether this is the case for all age groups is not clear. We examined the association between sUA concentrations and systolic and diastolic blood pressure (SBP and DBP) in different age groups in a cohort of healthy Chinese participants.A total of 1082 healthy participants aged from 41 to 70 years were included. sUA concentration was measured by the uricase-peroxidase method. SBP and DBP were assessed using mercury sphygmomanometry. Hypertension was defined as SBP ≥140 mm Hg or DBP ≥90 mm Hg. Hyperuricemia (HUA) was defined as sUA concentration of >7 mg/dL in men and >6 mg/dL in women. The association between sUA concentration and SBP and DBP was examined using Pearson's correlation test, multivariate linear regression, and logistic regression analysis.The prevalence of hypertension and HUA increased with age (P < .001). Hypertension was more common in participants that had HUA than in those that did not (38.95% vs 30.16%, P = .02). Higher sUA was significantly associated with higher SBP and DBP in the 41- to 50-year-old participants (SBP, β = 0.35, P < .001; DBP, β = .29, P < .001; after adjustment for age, sex, total cholesterol, estimated glomerular filtration rate, and fasting plasma glucose). HUA was also a risk factor for hypertension in this age group (odds ratio 1.425, 95% confidence interval, 1.217–1.668, P < .001). There was no association between sUA concentration and SBP and DBP in the other age groups.In this population of healthy Chinese participants, sUA concentration was positively associated with hypertension only in the 41- to 50-year-old group. Lowering uric acid in this age group may help to reduce the incidence of hypertension.
Colorectal cancer (CRC) is the third most common type of diagnosed cancer and the fourth leading cause of cancer‑associated mortalities worldwide. Increasing studies have demonstrated that the deregulation of microRNAs (miRNAs or miRs) is associated with the occurrence and development of multiple types of human cancer, including CRC. miR‑329 has been identified to be downregulated in various types of cancer; however, its expression pattern, functions and mechanisms in CRC remain unclear. The present study demonstrated that miR‑329 was lowly expressed in CRC tissue samples and cell lines. Low expression of miR‑329 was correlated with tumor‑node‑metastasis stage and lymph node metastasis in patients with CRC. In vitro experiments revealed that resumption expression of miR‑329 suppressed cell proliferation and invasion in CRC. Furthermore, the results of the present study indicated that miR‑329 targets transforming growth factor‑β1 (TGF‑β1) directly in vitro. TGF‑β1 was demonstrated to be upregulated in CRC tissue samples and inversely correlated with miR‑329 expression. Upregulation of TGF‑β1 was able to partially counteract the antitumor roles of miR‑329 on CRC cell proliferation and invasion. The results of the current study revealed that miR‑329 suppresses CRC cell proliferation and invasion through targeting TGF‑β1, thus suggesting that targeting miR‑329/TGF‑β1 may provide a novel effective therapeutic approach for the treatment of patients with CRC.
A 49-year-old man presented with superior vena cava syndrome (SVCS) over a period of one month, and intermittent bilateral upper extremities pain. He had been in good health until one month earlier, when he noted facial edema, hyperemia in the jugular and epigastric vein, and shortness of breath. The axial computed tomographic (CT) scan of the chest showed an anterior mediastinal mass with calcification and cyst (Fig 1C, D, red arrows), and filling defects caused by a tumor thrombus measuring approximately 16 cm within the brachiocephalic vein protruding into the superior vena cava (SVC) and the right atrium ( Fig 1A to F, green arrows). The coronal and sagittal reformation views of the chest CT displayed the anterior mediastinal mass (Fig 2B, red arrow) and the tumor thrombus (Fig 2A, B, green arrows) clearly. Chest CT scans also demonstrated multiple lung metastases, left pleural metastasis, and left pleural effusion on admission. A transthoracic echocardiogram demonstrated a thrombus in the right atrium. The patient underwent transthoracic CT-guided biopsy, which revealed a poorly differentiated squamous-cell carcinoma consistent with thymic carcinoma. The patient was placed on two cycles of docetaxel and cisplatin, and was considered to have had a partial response to chemotherapy. Two additional treatments of the abovementioned chemotherapy regimen were subsequently performed. He was also given warfarin to start anticoagulant therapy. Radiation was not performed in order to avoid thrombus shedding. A follow-up was performed after the therapy, however, the patient died six months after completion of the treatment because of multiple metastases and tumour cachexia. DiscussionThymic carcinoma is a rare tumor of the anterior mediastinum derived from the epithelial cells of the thymic gland, and the clinical behavior and prognosis of thymic carcinoma are reported to be correlated with its morphological features. 1-3Keywords right atrium; superior vena cava; thymic carcinoma; tumor thrombus. Correspondence
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