The response to temperature and glucose, high salt tolerance and self-regulated drug delivery are simultaneously probable by applying a multifunctional microgel in a rational design by a colloid chemistry method. Such smart microgels were fabricated with thermoresponsive N-isopropylacrylamide, glucose-sensitive (2-phenylboronic esters-1,3-dioxane-5-ethyl)methyl acrylate (PBDEMA) and water-soluble crosslinker poly(ethylene glycol) diacrylate through a precipitation emulsion method. These colloidal nanoparticles exhibited PBDEMA-composition-dependent responsive behavior with changing temperature and ionic strength. Amongst them, the microgel with 20.7 mol% PBDEMA with a narrow size distribution is suitable for diabetes treatment because it can adapt to the surrounding medium of different glucose concentrations over a clinically relevant range (0-2.0 mg mL −1 ), control the release of preloaded insulin and is highly stable under normal physiological conditions. Preliminary experiments suggest these highly stable microgels have the potential to be used for self-regulated therapy and monitoring the response to treatment.

The effective distribution of public storage materials is the key to realizing rapid and accurate rescue of territories, which could truly solve the “last kilometer” problem of emergency rescue. At present, it is relatively rare to study the rapid and accurate distribution of emergency supplies by taking demand forecasts, emergency reserves, and distribution models as an organic whole. In view of the bottleneck of rapid and accurate rescue in the complex disaster environment, this paper selects various means such as field research, literature retrieval, and previous case analysis and uses the system analysis method. Next, this paper explains that the three main factors that affect the distribution of public storage materials are the demand of “black box”, the scarcity of materials, and the blindness of distribution and constructs an effective analysis framework of demand predictability, material availability, and distribution accuracy. Finally, this paper puts forward the triangle structure framework of demand forecasting, virtual public storage, and comprehensive distribution and further explains the triangle structure relationship, operation mechanism, and operation strategy of effective distribution of public storage materials.