Children with Prader-Willi Syndrome (PWS) may present with a malocclusion and have a high propensity of developing obstructive sleep apnea (OSA). Obstructive sleep apnea is associated with short- and long-term adverse effects that negatively impact children with PWS. A case of a 15-year-old male with PWS, OSA, and a debilitating malocclusion is presented who underwent a combination of Le Fort 1 osteotomy, genioplasty, and tongue reduction to successfully treat his OSA and malocclusion. In select cases, orthognathic correction and other surgical therapies should be considered in patients with PWS.
The majority of GIB events occur early after CF-LVAD implantation and are primarily associated with older age. Patients in their fifth decade of life have 4.6 times the risk of GIB compared with those in their second decade. Nearly half of patients with GIB experience >1 GIB, and GIB is a significant driver of rehospitalization and transfusion, but rarely results in death.
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