Introduction This clinical randomized controlled trial evaluates the effectiveness of prednisolone mouthwash as a treatment modality for moderately advanced cases of oral submucous fibrosis. Materials and Method Sixty-four patients were enrolled for the study and randomized into two groups (n = 32 in each group). The experimental group was treated with prednisolone mouthwash and antioxidant capsule as per GDCH Nagpur protocol, and control group was treated with antioxidant capsule only. The primary outcome variables were interincisal mouth opening, burning sensation, and recurrent ulceration. Clinical responses were obtained at the time of the allocation, at 1, 3, 6, and 9 months into the intervention, and 6 months thereafter.
ResultsThe average increased mouth opening achieved was 10.46 mm (p \ 0.5) in group A (experimental group) and only 1.04 mm (p \ 0.5) mm in group B (control group). In addition, there was a significant difference in relief of burning sensation and recurrent ulceration. Relief of burning sensation and recurrent ulceration was within 12.81 and 10.93 days, respectively, in group A when compared to group B which was within 21.56 and 20.06 days, respectively.
ConclusionWe conclude that in our trial, prednisolone mouthwash with antioxidants was seen to be efficacious, safe, and reliable in the management of oral submucous fibrosis.
Soft tissue injuries of head and neck are the most common injuries encountered by the maxillofacial surgeons during their clinical practice. Therefore, one must have a sound knowledge of the various types, their mechanisms of injuries and most importantly, the management of the same. This chapter discusses the classification system of all types of soft tissue injuries, and focuses on the principles of management of different types of the injuries, with emphasis on their mechanism and healing process. Numerous figures, box diagrams and case scenarios are added to make the chapter interesting and provide real time information about the topic. A special note on necrotizing fasciitis, one of the most challenging infections in the head and neck region has also been mentioned along with information about wound dressings. Recent advances in the management of soft tissue injuries like use of growth factors, bioengineered skin substitutes and stem cell therapy are enumerated for the readers to encourage them about futuristic approaches. The authors hope that the readership attains a holistic knowledge about various aspects of the soft tissue injuries and their management.
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