Quebec Breast Cancer Foundation and Genome Canada Innovation Network. This trial was funded by the National Heart, Lung, and Blood Institute. For details see Acknowledgments.
Understanding the relationship between individuals’ social networks and health could help devise public health interventions for reducing incidence of unhealthy behaviors or increasing prevalence of healthy ones. In this context, we explore the co-evolution of individuals’ social network positions and physical activities. We are able to do so because the NetHealth study at the University of Notre Dame has generated both high-resolution longitudinal social network (e.g., SMS) data and high-resolution longitudinal health-related behavioral (e.g., Fitbit physical activity) data. We examine trait differences between (i) users whose social network positions (i.e., centralities) change over time versus those whose centralities remain stable, (ii) users whose Fitbit physical activities change over time versus those whose physical activities remain stable, and (iii) users whose centralities and their physical activities co-evolve, i.e., correlate with each other over time. We find that centralities of a majority of all nodes change with time. These users do not show any trait difference compared to time-stable users. However, if out of all users whose centralities change with time we focus on those whose physical activities also change with time, then the resulting users are more likely to be introverted than time-stable users. Moreover, users whose centralities and physical activities both change with time and whose evolving centralities are significantly correlated (i.e., co-evolve) with evolving physical activities are more likely to be introverted as well as anxious compared to those users who are time-stable and do not have a co-evolution relationship. Our network analysis framework reveals several links between individuals’ social network structure, health-related behaviors, and the other (e.g., personality) traits. In the future, our study could lead to development of a predictive model of social network structure from behavioral/trait information and vice versa.Electronic supplementary materialThe online version of this article (10.1007/s41109-018-0103-2) contains supplementary material, which is available to authorized users.
We perform spin noise spectroscopy experiments in metastable helium atoms at room temperature, with a probe light whose frequency is blue detuned from the D0 line. Both circular birefringence fluctuations (Faraday noise) and linear birefringence fluctuations (ellipticity noise) are explored theoretically and experimentally. In particular, it is shown that in both cases but for different optical detunings, two noise resonances are isolated at the Larmor frequency and at twice the Larmor frequency with a behaviour, which strongly depends on the orientation of the probe field polarization. The simple structure of metastable helium allows us to probe, model and explain the changes in the behavior of these peaks in terms of circular and linear dichroisms and birefringences as well as in terms of spin oscillation modes.
Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are two pathologically distinct chronic lung diseases that are associated with cigarette smoking. Genetic studies have identified shared loci for COPD and IPF, including several loci with opposite directions of effect. The existence of additional shared genetic loci, as well as potential shared pathobiological mechanisms between the two diseases at the molecular level, remains to be explored. Taking a network-based approach, we built disease modules for COPD and IPF using genome-wide association studies-implicated genes. The two disease modules displayed strong disease signals in an independent gene expression data set of COPD and IPF lung tissue and showed statistically significant overlap and network proximity, sharing 19 genes, including ARHGAP12 and BCHE. To uncover pathways at the intersection of COPD and IPF, we developed a metric, NetPathScore, which prioritizes the pathways of a disease by their network overlap with another disease. Applying NetPathScore to the COPD and IPF disease modules enabled the determination of concordant and discordant pathways between these diseases. Concordant pathways between COPD and IPF included extracellular matrix remodeling, Mitogen-activated protein kinase (MAPK) signaling and ALK pathways, whereas discordant pathways included advanced glycosylation end product receptor signaling and telomere maintenance and extension pathways. Overall, our findings reveal shared molecular interaction regions between COPD and IPF and shed light on the congruent and incongruent biological processes lying at the intersection of these two complex diseases.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.