Highlights d KLF10 expression is downregulated in mouse CD4 + T cells and human subjects with obesity d KLF10 deletion in mouse CD4 + T cells leads to multiple defects in CD4 + Treg function d Decreased TGF-b3 release from these Tregs alters glucose uptake and production d WT Treg delivery rescues obesity, insulin resistance, and fatty liver in these mice
Background: Heart failure (HF) is a complex and multifactorial syndrome caused by impaired heart function. The high morbidity and mortality of HF cause a heavy burden of illness worldwide. Non-thyroidal illness syndrome (NTIS) refers to aberrant serum thyroid parameters in patients without past thyroid disease. Observational studies have indicated that NTIS is associated with a higher risk of all-cause mortality in HF. This meta-analysis aimed to investigate the association between NTIS and HF prognosis.
Methods: Medline, Embase, Web of Science, and the Cochrane database were searched for any studies reporting an association between NTIS and HF prognosis from inception to July 1st 2022. A meta-analysis was then performed. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS). The heterogeneity of the results was assessed with I2 and Cochran's Q statistics. Sensitivity analysis and publication bias analysis were also conducted.
Results: A total of 626 studies were retrieved, and 18 studies were finally included in the meta-analysis. The results showed that NTIS in HF patients was significantly associated with an increased risk of all-cause mortality and major cardiovascular events (MACE), but not with in-hospital mortality. The stability of the data was validated by the sensitivity analysis. There was no indication of a publication bias in the pooled results for all-cause mortality and MACE.
Conclusions: This meta-analysis showed that NTIS was associated with a worse outcome in HF patients. However, the association between NTIS and in-hospital mortality of HF patients requires further investigation.
Background
Glyphosate-based herbicides (GBHs) are used extensively around the world and have become the leading agrochemicals. However, study about the association between glyphosate exposure and diabetes is scarce. This study used four years of NHANES data (2013–2016) to further investigate the association.
Methods
A total of 2,806 participants were enrolled in this cross-sectional study. The baseline information and urine glyphosate levels in diabetic and non-diabetic groups were compared. We also divided urine glyphosate levels into tertiles. Three models were developed using weighted logistic regression. Further subgroup analyses based on categorical variables were also conducted.
Results
Urine glyphosate levels were 0.35ng/ml in people with diabetes and 0.44ng/ml in participants without diabetes (P < 0.05). Regardless of adjustment, the highest glyphosate level in the tertile3 group was significantly linked with an elevated risk of diabetes (OR 1.595, 95% CI 1.016–2.504, P = 0.043) compared to the tertile1 group. Subgroup analyses suggested that the associations were constant in participants who were male, older age (60–100), had a college degree, income ratio = 5, BMI > 30, and smoking.
Conclusions
This study provides new evidence that glyphosate exposure was associated with a higher risk of diabetes in the American general adult population.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.