An efficient, one-pot, and cheap metal-catalyzed tandem Chan-Lam coupling/deprotection/oxidation reaction to access unsymmetrical azobenzenes is disclosed. In this protocol, phthaloyl is automatically fallen off under this basic catalytic system, without...
C–H annulations at N- and C2-aryls of an imidazole have been well researched, while the annulation on C4(5)-aryls especially the reactivity and site-selectivity among these aryls remain unknown. Herein, a...
Cu/Fe-mediated arylation of pyridines with arylboronic acids, featuring low-cost catalytic system and easy operation, is disclosed. A series of length-controllable linear (the number of aryls ranges from 2 to 6)...
An efficient one-pot synthesis of 1,1′-biisoquinolines
by
a three-component reaction of commercially available raw materials
(benzils, NH4OAc, and alkynes) is disclosed. This complicated
reaction involves in situ diimine formation via benzil-NH4OAc condensation, Rh(III)-catalyzed 2-fold imine-directed C–H
activation, and annulation with alkynes. Both symmetric and unsymmetric
1,1′-biisoquinolines could be assembled in moderate to high
yields. The reaction mechanism is supported through ESI-MS, in which
Cp*ClRh+, Cp*(OAc)Rh+, Cp*(OPiv)Rh+, and two rhodacycle intermediates are successfully detected to explain
the evolution of rhodium species.
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