Recently the application of crude drugs in cosrnetics has produced a keen interest. We learned from ancient Chinese rnedical books that crude drugs were applied as cosmetics with medical efficacy for increasing the beauty of ladies [I]; arnong which it was noted that many prescriptions were for the purpose of treating hyperpigrnentation such as melasrna and ephelides. However, the reasons'why such crude drugs were applied an also their pharmacological effects are lntroduction
We started to study on the development of EPA ethyl ester(EPA-E) for a drug in cooperation with doctors and pharmaceutical companies in 1979, and we were permitted to manufacture the drug for atherosclerosis obliterans named EPADEL in 1990. In this work, several methods were examined to purify EPA-E in fish oil ethyl ester mixture to pharmaceutical grade, and the distillation with mufti-tower system and cyclic process of urea adduction method were developed. By the combination of above two processes, 90% EPA-E was obtained from fish oil ethyl ester containing 18% EPA. Stability tests revealed that EPA-E in a closed container could be stored without any undesirable changes at room temperature for 2 years. Clinical studies clarified the effect of EPA-E on both atherosclerosis obliterans and hyperlipidemia.
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