Sodium bromate has been found to be effective oxidant for oxidation of alcohols in the presence of cerium or ruthenium compounds in biphase reaction. Selective oxidation of secondary alcohols was performed in the presence of primary ones using cerium(IV) ammonium nitrate (CAN) or cerium(IV) sulfate (CS) as catalyst. For instance, treatment of 1,10-undecanediol with CS/NaBrO3 provided 11-hydroxy-2-undecanone in 82% yield. Ruthenium catalyzed biphase oxidation of alcohols with sodium bromate provided the corresponding aldehydes or ketones in good to excellent yields.
Bis(trimethylsilyl) peroxide (BTSP) serves as an effective oxidant of alcohols in the presence of chromium(VI) or ruthenium(II) complexes as catalysts in dichloromethane. Selective oxidation of primary alcohols in preference to secondary ones using RuCl2(PPh3)3 as a catalyst is also described.
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