Regioselective Synthesis of 3-Aryl-5-(1H-indole-3-carbonyl)-4-hydroxyfuroicAcids as Potential Insulin Receptor Activators. -Model studies for the selective synthesis of C-5 methyl esters (III) from furan 2,5-dicarboxylic acids (I) and related thiophene derivatives such as (XIV) are presented. Coupling of the building blocks (IIIa) and (X) provides access to potential insulin receptor activators of type (XII). -(CHOU*, S.-Y.; CHEN, S.-S. T.; CHEN, C.-H.; CHANG, L.-S.; Tetrahedron Lett. 47 (2006) 43, 7579-7582; Dev. Cent. Biotechnol., Taipei 221, Taiwan; Eng.) -Mais 05-115
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