Cancer is a disease that can cause human death in various countries. According to WHO in 2018, cancer causes 9.6 million human deaths worldwide. Globally, about 1 in 6 deaths is due to cancer. Therefore, we need a technology that can be used for cancer detection with high acuration so that cancer can be detected early. Microarrays technique can predict certain tissues in humans and can be classified as cancer or not. However, microarray data has a problem with very large dimensions. To overcome this problem, in this study use one of the dimension reduction techniques, namely Partial Least Square(PLS) and use Support vector Machine (SVM) and K-Nearest Neighbors as a classification method, which will be used to compare which is better.The system built was able to reach 98.54% in leukemia data with PLS-KNN, 100% in lung data with KNN, 66.52% in breast data with PLS-KNN, and 85.60% in colon data with PLS- SVM. KNN is able to get the best in three data from four valued data.
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