A novel cascade reaction has been described for the synthesis of Carbolines via palladium‐catalyzed successive C–C/C–N formation from O‐methylketoximes and styrenes. The oxime ether auxiliary not only serves as a traceless directing group, but is also partly transformed into the value‐added pharmacophore in a two‐step, one‐pot fashion.
A novel route for ruthenium(II)-catalyzed αfluoroalkenylation of oxime ethers with gem-difluorostyrenes via C−H activation and C−F cleavage has been developed for the first time. Notably, the alkenyl units of products exhibit exclusive Zconfiguration. This reaction features a broad substrate scope and good functional group tolerance. A plausible reaction mechanism is confirmed by an available cycloruthenated intermediate. Besides, the O-methyl oximyl-directing group can be readily removed to access the α-fluoroalkenylated acetophenones.
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