A practical synthetic route towards 1,2,3-tri-O-acetyl-5-deoxy-D-ribofuranose from D-ribose is described, which started from D-ribose and proceeded through ketalization,esterification,reduction,hydrolysis and acetylation in more than 30% overall yield.
(S)-methyl 3-(((benzyloxy) carbonyl) amino)-7-hydroxyheptanoate (7), a fragment of a novel cytotoxic cyclodepsipeptide onchidin[, which shows moderate cytotoxic activity, was synthesized through six steps. The key stereoselective synthesis of beta-amino acid derivatives (7) was achieved by the Arndt-Eistert homologation reaction[2,3] and Wolff rearrangement reaction[4].
The bicyclo [3, 3, 1] nonane ring system is the main structural feature in the lycopodium alkaloids. There are many methods to build the [3, 3, 1] bridged ring system, Herein, we designed to use indium Lewis acid which can activate the triple bond to construct [3, 3, 1] bridged ring system via Conia-ene reaction, and described a prophase study of applying Conia-ene reaction to construct such bicycle [3, 3, 1] nonane ring.
A concise and practical synthetic study towards racemic Ieodomycin A was described, which started from commercially available 3,7-dimethyl-2,6-octadien-1-ol (geraniol) and proceeded through a key Mukaiyama aldol reaction.
(R)-2,2-Dimethyl-3-(tert-butoxycarbonyl)-4-ethynylox-azolidine, an intermediate of the natural product jaspine B, which was isolated from various sponges and endowed with cytotoxic activity against several human carcinoma cell lines, was synthesized fromL-Serine in overall yield 43% through seven steps, including esterification, Boc protection, acetonization, reduction, Swern oxidation and Corey-Fuchs reaction.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.