Idiopathic inflammatory myopathy (IIM) is the umbrella term including dermatomyositis (DM), polymyositis (PM), overlap myositis (OM), sporadic inclusion body myositis (IBM) and necrotising autoimmune myopathy (NAM), also known as immune‐mediated necrotising myopathy. There is some debate as to whether PM exists as a discrete entity, or perhaps is an overly generalising term encompassing connective tissue disease associated myositis, or OM, and the previously poorly recognised NAM. As such, PM will not be covered in detail in this review. DM, OM and NAM all present similarly, with proximal weakness and elevated creatine kinase (CK) level. By contrast, IBM preferentially involves the long finger flexors and quadriceps, and presents with a normal or only mildly elevated CK. Developments in serological testing and imaging are shifting the diagnostic paradigm away from a reliance on histopathology. The therapeutic armamentarium for IIM continues to evolve, with intravenous immunoglobulin and rituximab proving to be successful for refractory disease. This review will provide a diagnostic algorithm for the clinician to help distinguish between IIM subtypes – with emphasis on clinical assessment, serology and imaging, as well as discussion of therapeutic options and escalation of immunotherapy.
Background Before the role of shear wave elastography (SWE) and B mode ultrasound (US) in the diagnosis of different forms of idiopathic inflammatory myopathies (IIM) can be investigated, normative data is required. This study aimed to describe and then compare normative SWE and B mode ultrasound metrics of muscles in healthy controls and patients with IIM. Methods Twenty nine healthy adult controls and 10 IIM patients (5 with inclusion body myositis and 5 with necrotising autoimmune myopathy) underwent a full clinical examination, laboratory investigations, SWE and US measurements of selected proximal and distal limb muscles. Shear wave speed (SWS) and multiple US domains [echogenicity, fascial thickness, muscle bulk and power Doppler (PD)] were measured in both groups. Results In healthy controls (n = 29; mean age 46.60 ± 16.10; 44.8 % female), age was inversely correlated with SWS at the deltoid (stretch) (Rs. -0.40, p = 0.030) and PD score at the deltoid (rest) (Rs. -0.40, P = 0.032). Those ≥ 50 years old had a lower SWS at the deltoid (stretch) compared to the < 50 year group (2.92 m/s vs. 2.40 m/s, P = 0.032). Age correlated with increased echogenicity in the flexor digitorum profundus (Rs. 0.38, P = 0.045). Females had a smaller muscle bulk in the deltoid (P = 0.022). Body mass index (BMI) was inversely associated with SWS in the deltoid (stretch) (Rs – 0.45, P = 0.026), and positively correlated with echogenicity in the deltoid (Rs. 0.69, P = 0.026). In patients ≥50 years of age, patients with IIM (mean age 61.00 ± 8.18; females 20.0 %) had a higher proportion of abnormal echogenicity scores at the flexor digitorum profundus (FDP) (40.00 % vs. 14.30 %, P = 0.022) and tibialis anterior (TA) (80.00 % vs. 28.60 %, P = 0.004). Fascial thickness was lower in the FDP (0.63mm vs. 0.50mm, p = 0.012) and TA (0.58mm vs. 0.45mm, P = 0.001). Conclusions Our findings suggest there is scope for US techniques to be useful for diagnostic screening of affected muscles in patients with IIM, especially in those with suspected inclusion body myositis or necrotising autoimmune myopathy. We provide normative data for future studies into SWE and US techniques in skeletal muscle. The differences between IIM patients and controls warrant further study in a broader IIM patient cohort.
Background: There is a global concern that the emergence of antimicrobial resistance (AMR) threatens our ability to treat infectious diseases. The Canadian Antimicrobial Resistance Surveillance System (CARSS) was created in response to the Government of Canada's commitment to address AMR. CARSS integrates information from nine different national surveillance systems for tracking antimicrobial use (AMU) and AMR in both humans and animals to inform AMU/AMR research and policy.
Background B mode ultrasound (US) and shear wave elastography (SWE) are easily accessible imaging tools for idiopathic inflammatory myopathies (IIM) but require further validation against standard diagnostic procedures such as MRI and muscle biopsy. Methods In this prospective cross-sectional study we compared US findings to MRI and muscle biopsy findings in a group of 18 patients (11 F, 7 M) with active IIM (dermatomyositis 6, necrotising autoimmune myopathy 7, inclusion body myositis 4, overlap myositis 1) who had one or both procedures on the same muscle. US domains (echogenicity, fascial thickness, muscle bulk, shear wave speed and power doppler) in the deltoid and vastus lateralis were compared to MRI domains (muscle oedema, fatty infiltration/atrophy) and muscle biopsy findings (lymphocytic inflammation, myonecrosis, atrophy and fibro-fatty infiltration). A composite index score (1–4) was also used as an arbitrary indicator of overall muscle pathology in biopsies. Results Increased echogenicity correlated with the presence of fatty infiltration/atrophy on MRI (p = 0.047) in the vastus lateralis, and showed a non-significant association with muscle inflammation, myonecrosis, fibrosis and fatty infiltration/atrophy (p > 0.333) Severe echogenicity also had a non-significant association with higher composite biopsy index score in the vastus lateralis (p = 0.380). SWS and US measures of fascial thickness and muscle bulk showed poor discrimination in differentiating between pathologies on MRI or muscle biopsy. Power Doppler measures of vascularity correlated poorly with the presence of oedema on MRI, or with inflammation or fatty infiltration on biopsy. Overall, US was sensitive in detecting the presence of muscle pathology shown on MRI (67–100%) but showed poorer specificity (13–100%). Increased echogenicity showed good sensitivity when detecting muscle pathology (100%) but lacked specificity in differentiating muscle pathologies (0%). Most study participants rated US as the preferred imaging modality. Conclusions Our findings show that US, in particular muscle echogenicity, has a high sensitivity, but low specificity, for detecting muscle pathology in IIM. Traditional visual grading scores are not IIM-specific and require further modification and validation. Future studies should continue to focus on developing a feasible scoring system, which is reliable and allows translation to clinical practice.
BackgroundPsA can be difficult to distinguish from osteoarthritis (OA) and the treatments vary greatly. Nail involvement can occur in about 15–50% patients with psoriasis1, which may aid differentiation from OA. If US can reliably detect nail bed changes in early disease then it might be helpful in differentiating PsA from OAObjectivesThis study aims to investigate the nail bed changes seen in patients with PsA and OA using US and MRI, and to determine the impact of nail bed changes on quality of life (QOL).MethodsPatients who fulfilled the CASPAR PsA or 1990 ACR OA classification criteria were recruited. At baseline, clinical assessment included patient and physician's visual analogue scale (VAS), tender and swollen joints, patient's Leeds Enthesitis Index and quality of life specific to nail psoriasis (NPQ10). Nail abnormalities on the dominant hand such as onycholysis, pitting, nail bed hyperkeratosis and nail bed crumbling were documented. Using US, each nail (1–5) was scored dichotomously for pitting/irregularity, loss of normal trilaminar appearance of the nail. Each nail was scored semi quantitatively for power doppler (PD) signal (0–3) in the nail bed, nail matrix and dermis, and assigned a total PD score. All patients had an MRI of the dominant 2nd to 5th finger.Results14 patients were recruited; demographics, clinical and US detected nail changes are documented in Table 1. Clinical nail changes were not seen in the OA group, but were relatively common in the PsA group. In the PsA group, 54% of nails had US detected structural abnormalities; 12% pitting and 52% loss of trilaminar layer. Only 20% of OA nails had US detected abnormalities. There was a strong relationship between the presence of clinical nail change and US structural changes (chi square 10.769 df 1 p=0.001) but not PD signal score. There was no relationship between clinical or US detected nail scores and NPQ10, patient or physician VAS, swollen joint count or Leeds Enthesitis Index. MRI analysis is pending.Table 1Total (n=14)PsA (n=10)OA (n=4) Age (median (IQR))56.5 (52.2–63.2)55.0 (48.0–63.2)61.0 (55.2–73.5)Patient VAS (median (IQR))29.0 (12.5–54.839.5 (19.8–54.8)11.0 (3.8–54.2)Physician VAS (median (IQR))35.3 (20.5–57.5)42.5 (24.5–57.5)24.0 (4.8–53.8)NPQ10 (median (IQR))6.5 (1.8–10.0)7.0 (5.2–10.2)1.5 (0.2–5.8)Swollen joint count (median (IQR))2.0 (0.0–4.2)1.5 (0.0–5.2)2.5 (0.5–5.8)Leeds Enthesitis index (median (IQR))1.0 (0.0–2.0)1.0 (0.0–2.0)0.5 (0.0–1.8)Percentage of nails with clinical abnormalities27.7%40.0%0.0%Percentage of nails with US structural abnormalities44.3%54.0%20.0%Percentage of nails with PD signal97.1%96.0%95.0%ConclusionsIn this small prospective study, structural abnormalities detected by US appear to correlate well against clinical structural findings, but PD signal does not. No relationship was found between US findings and other clinical parameters. US structural abnormalities may be a better differentiator of PsA and OA than PD signal. MRI validation of these results is pending.References Gisondi P, Idolazzi L, Gi...
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