Background: Type 2 diabetes is a major illness that affects millions of people. The key causes of type 2 diabetes are insulin resistance and decreased insulin secretion Objectives: To evaluate the possible effects of ranolazine versus gliclazide on blood glucose levels,HbA1c, nitric oxide and oxidative stress markers in HFD/STZ-induced type 2 diabetes in male albino rats and their effect on the histopathological picture of the pancreas and on apoptosis. Materials and Methods: Thirty-two male albino rats were divided into four groups. The normal control group which received saline (1 mg/kg/day) for 5 weeks. The diabetic control group that received saline (1 mg/kg/day) for 5 weeks. The gliclazide-treated group that received gliclazide (10 mg/kg) twice daily for 5 weeks and the ranolazine-treated group that received ranolazine (20 mg/kg) twice daily for 5 weeks. Body weight and blood glucose levels were measured weekly for the 5 weeks, then blood samples were obtained for various biochemical analysis: lipid profile, HbA1c, AGEs and NO. Then rats were sacrificed and the pancreatic tissues were obtained for oxidative stress markers Medicine Updates Faculty of medicine
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