Active imagers capable of reconstructing 3-dimensional (3D) scenes in the presence of strong background noise are highly desirable for many sensing and imaging applications. A key to this capability is the time-resolving photon detection that distinguishes true signal photons from the noise. To this end, quantum parametric mode sorting (QPMS) can achieve signal to noise exceeding by far what is possible with typical linear optics filters, with outstanding performance in isolating temporally and spectrally overlapping noise. Here, we report a QPMS-based 3D imager with exceptional detection sensitivity and noise tolerance. With only 0.0006 detected signal photons per pulse, we reliably reconstruct the 3D profile of an obscured scene, despite 34-fold spectral-temporally overlapping noise photons, within the 6 ps detection window (amounting to 113,000 times noise per 20 ns detection period). Our results highlight a viable approach to suppress background noise and measurement errors of single photon imager operation in high-noise environments.

For the design of a passive autofocusing (AF) system for optical microscopes, many time-consuming and tedious experiments have been performed to determine and design a better focus criterion function, owing to the sample-dependence of this function. To accelerate the development of the AF systems in optical microscopes and to increase AF speed as well as maintain the AF accuracy, this study proposes a self-adaptive and nonmechanical motion AF system. The presented AF system does not require the selection and design of a focus criterion function when it is developed. Instead, the system can automatically determine a better focus criterion function for an observed sample by analyzing the texture features of the sample and subsequently perform an AF procedure to bring the sample into focus in the objective of an optical microscope. In addition, to increase the AF speed, the Z axis scanning of the mechanical motion of the sample or the objective is replaced by focusing scanning performed by a liquid lens, which is driven by an electrical current and does not involve mechanical motion. Experiments show that the reproducibility of the results obtained with the proposed self-adaptive and nonmechanical motion AF system is better than that provided by that of traditional AF systems, and that the AF speed is 10 times faster than that of traditional AF systems. Also, the self-adaptive function increased the speed of AF process by an average of 10.5% than Laplacian and Tenegrad functions.

Non-invasive optical imaging through opaque and multi-scattering media remains highly desirable across many application domains. The random scattering and diffusion of light in such media inflict exponential decay and aberration, prohibiting diffraction-limited imaging. By non-interferometric few picoseconds optical gating of backscattered photons, we demonstrate single photon sensitive non-invasive 3D imaging of targets occluded by strongly scattering media with optical thicknesses reaching 9.5l s (19l s round trip). It achieves diffraction-limited imaging of a target placed 130 cm away through the opaque media, with millimeter lateral and depth resolution while requiring only one photon detection out of 50,000 probe pulses. Our single photon sensitive imaging technique does not require wavefront shaping nor computationally-intensive image reconstruction algorithms, promising practical solutions for diffraction-limited imaging through highly opaque and diffusive media with low illumination power.

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Objective: The goal of this study is to explore the effect of wrist-ankle acupuncture combined with 5-Hz repetitive transcranial magnetic stimulation (rTMS) on improving spastic state and motor function of children with spastic cerebral palsy by measuring electrophysiological parameters and behaviors.Methods: Twenty-five children with spastic cerebral palsy were enrolled in a single-blind and randomized controlled trial. The control group received 20 sessions of 5-Hz rTMS over the affected hemisphere with 1,000 pulses. The experimental group was given wrist-ankle acupuncture on the basis of the control group. Gross motor function measure (GMFM-66), muscle tension, and electrophysiological parameters of the two groups were assessed at baseline and after intervention.Results: After treatment, the GMFM-66 scores in the same groups were significantly improved (p < 0.001). Besides, the R-value of soleus, gastrocnemius, and hamstring muscle decreased (p < 0.05), and the results showed a trend of shortening MEP latency, increasing amplitude and duration (p < 0.05). Compared to the controlled group, the experimental group displayed more excellent changes in the GMFM-66 scores and motor evoked potential (MEP) latency. The statistical results showed that the increase of GMFM-66 score and the shortening of MEP latency in the experimental group were greater than that in the control group (p < 0.05). However, no significant differences were found in the assessment of muscle tension, amplitude, and duration of MEPs between two groups (p > 0.05).Conclusion: Wrist-ankle acupuncture combined with 5-Hz rTMS is optimal to improve gross motor function and enhance the conductivity of corticospinal tract in children with cerebral palsy but cannot highlight its clinical superiority in improving spasticity.Clinical Trial Registration: [http://www.chictr.org.cn/index.aspx], identifier [chictr2000039495].

Non-line-of-sight (NLOS) optical imaging and sensing of objects imply new capabilities valuable to autonomous technology, machine vision, and other applications, in which case very few informative photons are buried in strong background counts. Here, we introduce a new approach to NLOS imaging and sensing using the picosecond-gated single photon detection generated by nonlinear frequency conversion. With exceptional signal isolation, this approach can reliably achieve imaging and position retrieval of obscured objects around the corner, in which case only 4 × 10−3 photons are needed to be detected per pulse for each pixel with high temporal resolution. Furthermore, the vibration frequencies of different objects can be resolved by analyzing the photon number fluctuation received within a ten-picosecond window, allowing NLOS acoustic sensing. Our results highlight the prospect of photon efficient NLOS imaging and sensing for real-world applications.

We demonstrate a photon-sensitive, three-dimensional (3D) camera by active near-infrared illumination and fast time-of-flight gating. It uses picosecond pump pulses to selectively upconvert the backscattered photons according to their spatiotemporal modes via sum-frequency generation in a χ 2 nonlinear crystal, which are then detected by an electron-multiplying CCD with photon sensitive detection. As such, it achieves sub-millimeter depth resolution, exceptional noise suppression, and high detection sensitivity. Our results show that it can accurately reconstruct the surface profiles of occluded targets placed behind highly scattering and lossy obscurants of 14 optical depth (round trip), using only milliwatt illumination power. This technique may find applications in biomedical imaging, environmental monitoring, and wide-field light detection and ranging.

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