Background: We aimed to study the feasibility of body surface projection in neuroendoscopic treatment of intracranial hemorrhage (ICH), and to evaluate the prognosis of muscle strength using diffusion tensor imaging (DTI) technique. Methods: We utilized 3D-SLICER software and adopted hematoma body surface projection orientation to eliminate ICH by using neuroendoscope for 69 cases of spontaneous intracerebral hemorrhage. The standard of correct location was determined by the direct view of hematoma at the first operation. Evacuation rate by comparing computed tomography (CT) before and after the surgery and Glasgow coma scale (GCS) was computed. DTI was used for pyramidal tract imaging 3 weeks after the operation, while the prognosis of muscle strength was assessed after 6 months. The control group included 69 patients with basal ganglia hemorrhage who received conservative treatment during the same period. Results: The hematoma evacuation rate was 90.75% in average. The average GCS score rose by 4 points one week after the surgery. The shape of pyramidal tract affected the prognosis of body muscle strength, and the simple disruption type was the worst. There was no difference in mortality between the surgery group (10.1%) and the conservative group (4.3%). The muscle strength improvement value and modulate RANK score (MRS) in the surgery group were better than the control group. Conclusion: It is convenient and feasible to use the surface projection to determine the target of operation, and the clearance rate of hematoma is high. Pyramidal tract imaging can predict the prognosis of muscle strength.

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In citric acid-based carbon dots, molecular fluorophore contributes greatly to the fluorescence emission. In this paper, the nitrogen and sulfur co-doped carbon dots (N,S-CDs) were prepared, and an independent sulfur source is selected to achieve the doping controllability. The influence of sulfur doping on the molecular fluorophore was systematically studied. The introduction of sulfur atoms may promote the formation of molecular fluorophore due to the increased nitrogen content in CDs. The addition surface states containing sulfur were produced, and S element exists as –SO3, and –SO4 groups. Appreciate ratio of nitrogen and sulfur sources can improve the fluorescence emission. The photoluminescence quantum yields (PLQY) is increased from 56.4% of the single N-doping CDs to 63.4% of double-doping CDs, which ascribes to the synergistic effect of molecular fluorophores and surface states. The sensitivity of fluorescence to pH response and various metal ions was also explored.

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