Background: CD226 is an activating receptor on NK cells that mediates NK cell cytotoxicity. Results: The first extracellular domain of CD226 (CD226-ECD1) mediates NK cell recognition, adhesion, immune synapse formation, and cytotoxicity against target cells. Conclusion: CD226-ECD1 retains almost all functions of the full-length CD226 protein.Significance: The conclusion is helpful to understand the mechanism by which CD226 recognizes its ligands.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.