We propose an admission control method in Network-on-Chip (NoC) with a centralized Artificial Neural Network (ANN) admission controller, which can improve system performance by predicting the most appropriate injection rate of each node via the network performance information. In the online control process, a data preprocessing unit is applied to simplify the ANN architecture and make the prediction results more accurate. Based on the preprocessed information, the ANN predictor determines the control strategy and broadcasts it to each node where the admission control will be applied. Compared to the previous work, our method builds up a high-fidelity model between the network status and the injection rate regulation. The full-system simulation results show that our proposed method can enhance application performance by 17.8% on average and up to 23.8%.
Alternative antibody-binding affinity ligands are expected to support robust time-and cost-effective antibody purification with rapid improvement of upstream productivity and demand on downstream process optimization. Five new tetrapeptide biomimetic affinity ligands (FYRH, HWRH, YHRI, HYRF, and FHRA) were screened by modeling the molecular interaction mechanism between tetrapeptide ligands and the Fc fragment of IgG with molecular dynamics simulation and the flexible docking method, and the corresponding five resins were prepared in this work to evaluate their adsorption characteristics of human immunoglobulin G (hIgG). The results showed that the binding capacities to hIgG of the five resins showed a strong pHdependency, which was high at pH 7.0−9.0, and extremely low at pH 5.0−6.0, providing a benefit choice to separate hIgG. The dynamic binding capacities (DBC) at 10% breakthrough of five resins could reach up to 28−37 mg/mL gel , and Ac-FYRH-4FF resin showed the best adsorption performance. The elution test results with Ac-FYRH-4FF resin indicated that hIgG could be eluted mildly at pH 5.0 with a 96.5% recovery, meaning that this resin can be considered as a powerful candidate of alternative biomimetic affinity chromatographic resin.
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