Single-crystal nickel-rich cathode materials (SC-NRCMs) are the most promising candidates for next-generation power batteries which enable longer driving range and reliable safety. In this review, the outstanding advantages of SC-NRCMs are discussed systematically in aspects of structural and thermal stabilities. Particularly, the intergranular-crack-free morphology exhibits superior cycling performance and negligible parasitic reactions even under severe conditions. Besides, various synthetic methods are summarized and the relation between precursor, sintering process, and final single-crystal products are revealed, providing a full view of synthetic methods. Then, challenges of SC-NRCMs in fields of kinetics of lithium diffusion and the one particularly occurred at high voltage (intragranular cracks and aggravated parasitic reactions) are discussed. The corresponding mechanism and modifications are also referred. Through this review, it is aimed to highlight the magical morphology of SC-NRCMs for application perspective and provide a reference for following researchers.
The wastewater containing polyphenol
(hydroquinone, catechol, and
resorcinol) is often found in many industrial processes. Liquid–liquid
extraction is a commonly used method to separate this style wastewater.
The liquid–liquid equilibrium for the quaternary systems of
water + polyphenol (hydroquinone, catechol, and resorcinol) + methyl
isobutyl ketone (MIBK) + toluene were measured at 298.15 K and 0.1
MPa. The potential for the mixture of MIBK + toluene to extract the
polyphenol from its aqueous solution was examined, and the distribution
coefficient and selectivity were used to evaluate the extractive ability
for the mixed solvent of toluene and MIBK. The results show that mixed
solvent has better extraction ability compared with single extractant
(MIBK). The nonrandom two-liquid and universal quasi-chemical models
were used to correlate experimental data, and the binary interaction
parameters were obtained. The values of room-mean-square-deviation
(RMSD) were used to evaluate the feasibility of the two models for
the systems and all the values of RMSD were less than 2%, which shows
that the two models can correlate the experimental data properly.
Clinical relevance: MicroRNAs (miRNAs) have been reported to be involved in the progression of various diseases. Studying the regulatory mechanisms of miRNAs can help clinical treatment. Background: Diabetic retinopathy (DR) is one of the complications of diabetes. The objective of this study was to elucidate the underlying molecular mechanisms by which miR-200c-3p regulates the pyroptosis of DR cell. Methods: Human retinal microvascular endothelial cells (HRMECs) and high glucose (HG) cultures established DR cell model in vitro. RT-qPCR is used to detect the expression level of miRNAs. CCK-8 assays and flow cytometry are used to detect apoptosis of HRMECs cell. Western blotting is used to detect cleaved caspase-3, cleaved caspase-1, and N-GSDMD proteins levels in HRMECs. The ELISA assay is used to detect the expression of IL-1β and IL-18. Predict and validate potential binding sites between miR-200c-3p and SLC30A7 by dual luciferase reporter gene analysis. Results: The results showed that HG caused damage to HRMECs through the pyroptosis pathway rather than the apoptosis pathway. MiR-200c-3p is highly expressed in HG induced-HRMECs, and knockdown of miR-200c-3p mitigates HG-induced HRMECs pyroptosis. MiR-200c-3p negatively targets SLC30A7 in HRMECs, and miR-200c-3p regulates pyroptosis of HG-induced HRMECs by targeting SLC30A7. Conclusion: The results suggest that miR-200c-3p might be a promising interference target for DR prevention and treatment. The results of current study may provide new insights into development of therapeutic strategies for DR.
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