Line of therapy (LoT); confidence interval (CI); first line of therapy (1L); second line of therapy (2L).
Extended Data Table 2 | Validation on progression-free survival hazard ratioThe number of inclusion and exclusion criteria, the number of eligible patients and the hazard ratio of progression-free survival with confidence interval of emulated aNSCLC trials with eligibility criteria under three scenarios: original criteria of the clinical trial, fully relaxed criteria and data-driven criteria learned from results of the hazard ratio of overall survival (same as in Table 1).
Article Extended Data Table 3 | Analysis in other cancersEligibility criteria for colorectal cancer (CRC), advanced melanoma and metastatic breast cancer in three scenarios. The number of inclusion and exclusion criteria, the number of eligible patients and the hazard ratio of the overall survival with confidence interval of emulated aNSCLC trials with eligibility criteria under three scenarios: original criteria of the clinical trial, fully relaxed criteria and data-driven criteria.
adoption of an EMR facilitated a significant increase in chart reviews and antimicrobial recommendations, which resulted in a sustained decrease in antimicrobial use. There were decreased nosocomial infections with MRSA and a trend towards decreasing CDIs following implementation of the EMR.
Socioeconomic disparities in health appear to persist into old age in the Mexican context. Efforts to reduce late-life health disparities in Mexico should target socioeconomic and material conditions across the life course.
This study identified two clusters with shared cognitive phenotype profiles that were not proxies for clinical diagnoses. The finding of better social cognitive performance of BD patients than SZ patients in the Lowe cluster suggest that relatively preserved social cognition may be important to identify disease process distinct to each disorder.
Individuals with schizophrenia often show substantial deficits in social cognitive abilities, which are strongly associated with social functioning. To advance our understanding of the genetic variation that is associated with social cognitive deficits in schizophrenia, we genotyped 74 schizophrenia outpatients who completed social cognitive performance measures assessing mentalizing, social perception, and emotional intelligence, as well as clinical symptoms. We assessed seven single nucleotide polymorphisms (SNPs) of the oxytocin receptor (OXTR) previously found to show replicable associations with socio-emotional processes. For one of the seven SNPs, rs2268493, the ‘T’ allele was significantly associated with poorer performance on a composite social cognition index, as well as specific tests of mentalizing and social perception. None of the SNPs were associated with clinical symptoms. Though the sample size is small, these findings provide initial support for the involvement of genetic variants of the OXTR in social cognitive impairments in schizophrenia.
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