CD25 on CD117+ mast cells, (iv) serum tryptase levels >20 mL plus one or more "C-findings"(cytopenia, malabsorption, osteolysis, liver impairment and ascites). 7 Our patient had the major criteria, two minor criteria and C findings.Aggressive systemic mastocytosis is a difficult to treat condition and treatment options include antihistaminics, H2 antagonists, disodium cromoglygate, corticosteroids, psoralen ultraviolet A, interferon alpha-2b and tyrosine kinase inhibitors. There is limited information in the literature to guide treatment of patients such as ours, with multisystem infiltration of mast cells causing multiple organ failure.Tyrosine kinase inhibitors have been shown to cause mast cell apoptosis, but their use in infants or neonates has been rarely reported. 8 Antibiotics are indicated in cases with features of sepsis. This case highlights the rapidly progressing course of aggressive systemic mastocytosis in a neonate and the need to develop aggressive treatment options to improve prognosis in patients, especially of this age group, which is otherwise very poor. Declaration of patient consentThe authors certify that they have obtained all appropriate patient consent forms. In the form, the legal guardian has given his consent for images and other clinical information to be reported in the journal. The guardian understands that names and initials will not be published and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.
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