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328ChemInform Abstract The racemic myo-inositol (Ia) is converted by a known procedure to a mixture of the bis-isopropylidene derivatives (Ib)-(Id) which are isolated as benzoates (IVa)-(IVc). In contrast to (IVb) and (IVc), a pure sample of (IVa) cannot be obtained and therefore a pure sample of its parent compound (Ib) is synthesized via the allyl ether (IVd). The allyl ethers (IVd)-(IVf) obtained from (Ib)-(Id) are separated and each is transformed to the respective di-O-allyl-myo-inositol (V). Kinetic acetonation of (Vb) gives the compound (VII). The desired pure (Ib) is then obtained from (IVd) (yield given in mg) by removing the allyl groups by isomerization and subsequent removal of the propen-1-yl groups formed using HgO/HgCl2. -Crystals of the diacetate (IX), obtained from (Vc) as outlined in the scheme (no yield given), show interesting 'jumping' behavior on heating and cooling.

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SUMMARYLipid metabolism in cells infected with adenovirus type 5 was studied using [32P]orthophosphate and [x~C]acetate precursors. Within the first 6 hr after infection, uptake of isotopes into cellular lipids was increased, although at this time no qualitative changes in the pattern of labelling were observed. At 12 to 18 hr after infection there was a markedly increased uptake of [x4C]acetate into cellular triglycerides. Increased lipid metabolism was demonstrated using ultravioletirradiated virus and purified penton base capsid subunits as well as whole infective virus. Highly purified adenovirus type 5 from cells labelled with [~P]orthophosphate during infection contained small amounts of radioactive lipid; the data presented suggest that this represented cellular lipid which remained attached to the virus, rather than lipid intrinsic to the virus particle.