Background: Blood transfusion is associated with a number of complications. Transfusion transmitted infections (TTI) are one of the major health problem in Bangladesh. Objective: The objective of the present study was to assess the status of transfusion transmitted infections among the apparently healthy donors. Methods: This study we carried out among 585 blood donors in the transfusion medicine department from April 2013 to March 2014 at National Institute of Neurosciences (NINS) and Hospital in Dhaka, Bangladesh. All the samples were screened for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), human immunodeficiency virus (HIV) 1 and 2, venereal disease research laboratory test (VDRL) and malaria to see the prevalence of TTI. Results: Prevalence of hepatitis B virus (HBV), HCV, and syphilis were 1.20, 0.68 and 0.34% respectively. No blood donor tested showed positivity for malarial parasite and HIV. Conclusion: Mandatory screening of donated blood and use of sensitive screening test should be done to

Introduction: Acute kidney injury (AKI) is an important clinical problem in sick neonate. In most patients, AKI accompanies with a predisposing factor such as sepsis, asphyxia and surgery. The aims of this study were to determine the incidence, associated contributing factors and short term outcome of AKI in hospitalized newborn infants. Materials and Methods: This prospective cohort study was done in Dhaka Shishu Hospital from March 2011 to September 2011. This study included 300 sick neonates admitted during the study period. AKI was defined when serum creatinine level >1.5 mg/dl and BUN was >20 mg/dl on two separate occasions at 24 hours apart. Oliguria was defined as urine output <1ml/kg/ hr. Medical records of those patients were reviewed and data were analyzed using SPSS software.Results: Fourteen babies (4.66%) out of 300 sick neonates had AKI, of whom 64.2% were male and 35.7% female. The term and preterm neonates were 71% and 29% respectively. While a normal birth weight was observed in 57% cases, 35% had low birth weight and 7.14% had very low birth weight. Sepsis was the most common (71%) association of AKI, followed by perinatal asphyxia (52%). All patients had more than one predisposing factors. Frequency of oliguric kidney injury was 57% and non-oliguric was 43%. Mortality among the hospitalized neonate with AKI was 21%.Conclusion: This study showed that in a tertiary care hospital AKI is not uncommon (4.66%) in neonatal care unit. It is associated with some preventable conditions such as sepsis, perinatal asphyxia and shock. Outcome is poor in sick neonates with AKI (21% mortality) in comparison to sick neonates without AKI (10.3%).

Background: Blood transfusion is associated with a number of complications. Transfusion transmitted infections (TTI) are one of the major health problem in Bangladesh.Objective: The objective of the present study was to assess the status of transfusion transmitted infections among the apparently healthy donors.Methodology: This study we carried out among 12,294 blood donors from September 2009 to March 2010 at Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. All the samples were screened for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV), human immunodeficiency virus (HIV) 1 and 2, venereal disease research laboratory test (VDRL) and malaria to see the prevalence of TTI.Results: Prevalence of HBV, HCV, HIV, and syphilis were 0.009, 0.0004, 0.0001 and 0.0001% respectively. No blood donor tested showed positivity for malarial parasite.Conclusion: Mandatory screening of donated blood and use of sensitive screening test should be done to reduce TTI in Bangladesh.J Shaheed Suhrawardy Med Coll, June 2014, Vol.6(1); 11-13

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread across the world. We describe two cases of neonate, presenting with features like multisystem inflammatory syndrome (MIS-C), who presented to our neonatal unit of Dr. M R Khan Shishu Hospital, Bangladesh on August, 2020.Case 1 was a 7-day-old male infant presented at 14 hours of life with fever, poor feeding, per rectal bleeding and shock. Detailed examination revealed Down’s fancies and pallor. Case 2 was 15-day old neonate presenting with fever, rash and convulsion and his laboratory values were remarkable for high levels of C-reactive protein, D-dimer, ferritin and his Cerebrospinal fluid (CSF) findings were consistent with aseptic meningitis. Both babies were tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). First case was very critical and referred to tertiary care hospital after stabilization. 2nd case recovered completely and was discharged to home in 15 days. Though till date COVID 19 in neonate is not very well-known to us, it is essential to disseminate information among the medical community regarding severe and atypical presentations of COVID-19 in neonate as prior knowledge can help to quickly identify and treat these patients as they present in the neonatal department. Bangladesh Journal of Infectious Diseases 2020;7(2):102-106

Ataxia telangiectasia (AT) is a complex multisystem disorder characterized by progressive neurological impairment, variable immunodeficiency and occulo-cutaneous telangiectasia. Ataxia telangiectasia is a member of chromosomal breakage syndromes and it is caused by a mutation in the ataxia-telangiectasia mutated (ATM) gene. We are reporting an eight year old girl of AT presented with difficulty in walking, frequent fall, trembling of the whole body, difficulty in speech. [J Shaheed Suhrawardy Med Coll, 2014;6(1):41-43]