Novel rhodanine-based amide derivatives were prepared in good yields via Passerini reaction of rhodanine-
N
-acetic acid with aromatic aldehydes and
tert
-butyl isocyanide in the presence of tetramethylguanidine immobilized on silica nanoparticles (TMG-SiO
2
NPs) as a heterogeneous base catalyst. The synthesized compounds were evaluated for their antibacterial effects against
Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus
and
Bacillus subtilis
.
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