This study was carried out to indicate the histological changes of mebeverine drugon the renal structure of pregnant white rats and their fetuses for a pregnancy period of 20 days,the number of rats used in this study was 20 female and male rats of type Rattusr attus (Sprague Dawley strain), 10 of them were fertile male rats with an average age of (10.5) weeks and an average weight of (231)g,the male rats were used for mating only, and the rest rats were 10 adult female rats with an average age of (11.5) weeks and an average weight of (240) g. The experiments of the current study were conducted in the Department of biology of the Faculty of Education for Girls/University of Kufa for the period from 10/6/2021 to 1/1/ 2022, males and females of rats were mated for the purpose of obtaining the pregnant rats required in this study which were 10 pregnant rats which were divided into two groups:one of the two groups was the control group which it was treated with physiological salt solution only and contained 5 pregnant rats,while the other group was treated with mebeverine drug at a concentration....
The aim: The researchers wanted to discover if Origanum majorana (O. M.) has any renoprotective qualities in a CIN rat model. Materials and methods: Control, ciprofloxacin (ciprofloxacin-induced CIN), two O. majorana groups (rats treated with O. majorana 30 mg and 45 mg), and two ciprofloxacin Plus O. majorana groups (n = 8) were randomly assigned to rats (CIN rats treated with O. majorana at 30 mg and 45 mg). Renal function tests were performed, as well as histological investigation. Results: The levels of serum blood urea nitrogen (BUN) and creatinine increased after ciprofloxacin treatment. The serum BUN and creatinine levels in the ciprofloxacin + O. majorana groups were lower as well as in O. majorana groups, however, kidney damage was higher in the ciprofloxacin group and reduced tissue damage in combination groups and O. majorana groups rats. Conclusions: O. majorana decreases experimental CIN in vivo. This effect is thought to activate the antioxidant defenses pathway.
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