Objective: develop and evaluate an analytical methodology using uv/vis spectroscopy for quantification of industrialized and compounded shampoos, and perform a physicochemical characterization in the products, including the content of zinc pyrithione. Methods: the validation of the analytical method was performed following the parameters of specificity and selectivity, linearity, precision, accuracy, and robustness established by anvisa in rdc nº 166/2017, validation of analytical procedures: text and methodology (complementary guideline on methodology dated 6 november 1996 incorporated in november 2005) and analytical procedures and methods validation for drugs and biologics (fda). The following assays of physical-chemical characterization were performed for both zinc pyrithione shampoo and placebo formulation: organoleptic characterization, ph, conductivity, content, foam index and viscosity. Results: the method was precise, repeatability obtained cv% between 3.71 and 3.91%, complying with the resolution. The study of intermediate precision also was in accordance with the resolution, which value obtained for cv% was between 3.17 and 3.79%. Results did not show statistically significant differences (p0.005). Accuracy had a slight variation, regarding to 100% of active principle. The method was considered robust. Sample a content presented a concentration of zinc pyrithione inferior to the recommended in the literature. Conclusion: the presented methodology showed to be simple and cheap through uv/vis-spectrophotometry. It is important to characterize the final product in order to provide the desired effect.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.