Background The aim of this study was to evaluate longitudinal changes in body composition after laparoscopic and open gastrectomies for gastric cancer. Methods Body mass, arm muscle mass, leg muscle mass, and fat mass were measured by performing a bioelectrical impedance analysis using a ''Bodyscan'' body composition analyzer (HXE19-JA; Konami, Tokyo, Japan) in 41 patients who had undergone gastrectomy: 14 patients underwent open distal gastrectomy, 8 patients underwent open total gastrectomy, and 19 patients underwent laparoscopy-assisted distal gastrectomy. All measurements were obtained preoperatively and at 1, 3, and 6 months after the operation. Results Fat mass decreased significantly throughout the 6-month period after distal gastrectomy and until 3 months after the laparoscopic surgery, while similar reductions in the total muscle mass and limb muscle mass were observed only in the first month after operation for all three groups. Patients with the laparoscopic approach had completely regained muscle mass at 6 months postoperatively. Conclusion Both fat and muscle mass reductions were responsible for the body weight loss during the first postoperative month, whereas loss of fat mass contributed to further weight loss after that period. Enhanced recovery of muscle mass at 6 months after laparoscopic surgery suggests the benefit of this surgery, among other factors.
Background and ObjectivesUridine-diphosphate glucuronosyltransferase 1A (UGT1A) is a key enzyme involved in irinotecan metabolism, and polymorphisms in the UGT1A gene are associated with irinotecan-induced toxicity. The aim of this study was to elucidate the allele frequencies of UGT1A polymorphisms in healthy Uzbek volunteers, and to compare them with those of the Japanese population.MethodA total of 97 healthy volunteers from Uzbekistan were enrolled and blood samples were collected from each participant. Genotyping analysis was performed by fragment size analysis for UGT1A1*28, direct sequencing for UGT1A7*3 and UGT1A9*22, and TaqMan assays for UGT1A1*93, UGT1A1*6, UGT1A1*27, UGT1A1*60, and UGT1A7*12. The frequencies of polymorphisms were compared with the Japanese population by using the data previously reported from our study group.ResultsWhen the Uzbek and Japanese populations were compared, heterozygotes or homozygotes for UGT1A1*28, UGT1A1*60, and UGT1A1*93 were significantly more frequent in the Uzbek population (P < 0.01). The rate of UGT1A7*12 was not significantly different between the two populations, whereas UGT1A1*6 and UGT1A9*22 were significantly less frequent in the Uzbek population (P < 0.05). UGT1A7*1 were less prevalent in the Uzbek population than in the Japanese population (P < 0.01).ConclusionThe Uzbek population has different frequencies of polymorphisms in UGT1A genes compared with the Japanese population. A comprehensive study of the influence of UGT1A1 polymorphisms on the risk of irinotecan-induced toxicity is necessary for optimal use of irinotecan treatment.
In suitable cases of HHD, MIS seems to be a good alternative to traditional OS for it is comparably safe and with a better postoperative outcome and a shorter postoperative rehabilitation period. Based on this experience we can advice MIS in selected patients with definitive indications.
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