Phase III, clinical trials on collagenase for treatment of Dupuytren's contractures have recently been completed. Meeting primary and secondary objectives, collagenase has obtained FDA approval for clinical use. Collagenase now provides a non-operative option for Dupuytren's disease. Although short-term results show that collagenase is safe and efficacious, long-term effects of repeat injections and contracture recurrence rates have yet to be examined.
Felons and paronychias are common fingertip infections of the hand that can lead to significant disability if left untreated. Although treatment principles have remained relatively unchanged over the years, new chemotherapeutic agents and multi-drug resistant bacteria may give rise to an increased number of complicated and aggressive cases seen by the treating physician. This up-to-date review focuses on the current accepted practice guidelines for the diagnosis and treatment of felons and paronychias. Specifically, a special emphasis is placed on more recently published studies.
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