BACKGROUND Marfan syndrome is an inherited systemic connective tissue disorder primarily associated with skeletal, cardiovascular and ocular pathology. Clinically affected persons have overgrowth of the long bone, thickening of atrioventricular valve and lens dislocation. MATERIALS AND METHODS A hospital-based clinical study was carried out on patients complaining of diminished vision in the Outpatient Department of Ophthalmology, Patna Medical College and Hospital. Patients of all age group with inclusive criteria of Marfan syndrome were studied. RESULTS This syndrome has no ethnic or gender preference and shows high penetrance but variable expression, both interfamilial and intrafamilial clinical variation is common. CONCLUSION The ocular complications commonly occur in Marfan syndrome as bilateral spontaneous posterior lens dislocation, retinal detachment and secondary glaucoma.
Solid Papillary Carcinoma (SPC) of the breast is a rare tumor with an incidence of less than 1%, mainly affecting elderly females. It is morphologically characterized by well-defined nodules with low-grade nuclear features associated with fibrovascular cores and shows neuroendocrine differentiation. SPC can be in-situ or invasive but has a favorable prognosis. It is a morphological mimicker of some pre-malignant conditions leading to its frequent misdiagnosis. An appropriate immunohistochemical (IHC) panel workup helps in distinguishing this tumor from its various morphological mimics. In this report, we present one such case of SPC with a small focus of invasion, reviewing the literature.
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