We have developed an efficient cyanuric chloride (2,4,6-trichloro-1,3,5-triazine, TCT) catalyzed approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one (3a-3x), 2-spiroquinazolinone (5, 7), and glycoconjugates of 2,3-dihydroquinazolin-4(1H)-one (10a, 10b) derivatives. The reaction allows rapid cyclization (8-20 min) with 10 mol % cyanuric chloride to give skeletal complexity in good to excellent yield. We believe that this novel procedure may open the door for the easy generation of new and bioactive quinazolinones.

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Novel β-carboline–quinazolinone hybrids are able to inhibit Leishmania donovani TR (LdTR). Molecular docking studies to investigate possible binding sites were performed.

New chloroquinolinyl arylsulfonamides with potential antimalarial activity inhibited hemozoin formation exceedingly well.