Mrityunjay is a plant based ayurvedic preparation which is used in the treatment of high blood pressure as well as other cardiovascular diseases. It comprises of significant cardioprotective constituents. This study was conducted to evaluate the effect of Mrityunjay on digoxin-induced arrhythmia and lipid profile in rats. Rats were orally pre-treated with Mrityunjay at the doses of 0.28 and 2.8 mL/kg b.w. for consecutive 35 days through the oral route. On the 36 th day, the rats were given a bolus dose of digoxin (20 mg/kg b.w., i.p.). Electrocardiogram along with heart rate were taken for an hour after digoxin administration and serum lipid profile was measured. The digoxin administration caused severe arrhythmia in rats. Mrityunjay significantly (p<0.05) inhibited digoxin-induced arrhythmia at both dose levels. In addition, it caused a significant (p<0.05) decrease in total cholesterol, low-density lipoprotein cholesterol and an increase in high-density lipoprotein cholesterol levels in blood serum. The study revealed that the ayurvedic preparation Mrityunjay possesses significant anti-arrhythmic activity against digoxin-induced arrhythmia. It also has a significant hypocholesterolemic effect.
Lauhasab, an Ayurvedic preparation, is widely used in anemia and cardiovascular diseases. Despite its claim as a cardio-tonic there is paucity of studies on pharmacological activities and toxicities. In this study, the anti-arrhythmic effect and impact on lipid profile were evaluated. Rats were pretreated with 0.28 and 2.8 ml/kg body weight of Lauhasab for 35 days and electrocardiographic tracings were recorded and analyzed to determine heart rate and occurrence of arrhythmia. Electrocardiogram recorded before digoxin administration showed significant decrease in mean heart rate along with longer duration of bradycardia than in digoxin control group after 35 days of chronic pretreatment with both doses of Lauhasab. In animal experiments, various arrhythmias were observed after intraperitoneal injection of digoxin. Lauhasab decreased the duration and delayed onset of time of various arrhythmias. It showed significant increase in cholesterol and triglyceride levels in a dose dependent manner. It can be concluded that Lauhasab possesses significant anti-arrhythmic activity against digoxin-induced arrhythmia. It also revealed hyperlipidemic effects.
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