Two categories of therapy are present, alpha adrenergic receptor antagonist and calcium. Recently, for distal ureteral calculi, good consequences have been shown by MET, related to stone removal and lessen the ureteral colicThe third most frequent disease of urinary tract in whole world is urolithiasis, which effect usually two-percent population with almost fifty [ 1 ] percent recurring rate . Ureteric stone occupies a main place in routine medical practices and experts are demanded to [ 2 ] r e c o m m e n d a p p r o p r i a t e t r e a t m e n t s . R e c e n t l y, b y u s i n g t h e t h e r a p i e s o f p h a r m a c o l o g y, u s e o f p e r c e p t i ve wa i t [3] approaches have been expanded . Medical expulsive therapy [MET] is suggested to elevate stone crossing and decrease the requirement of [4] extracorporeal shock wave lithotripsy . Most of the patients with urolithiasis contain stones of small size that are present in distal ureter and able to cross continuously. Removal of stone and time to move the stones depends upon size [5] of stone and it's location . RESULTS:Mean age was 32.29 ± 6.81 years. Out of these 86 patients, 53 (61.63%) were male and 33 (38.37%) were females with. Mean size of stone was 6.69±1.49 mm. Stone expulsion was seen in 37 (86.05%) patients in group A (tamsulosin group) and 25 (58.14%) patients in group B (nifedipine group) with p-value of 0.004. OBJECTIVES:To compare the efficacy (in terms of stone expulsion) of tamsulosin versus nifedipine in victims with distal ureteral stone. MATERIAL AND METHOD: All of 86 patients with distal ureteric stone, 20 to 50 years of both genders were included. Patients with proximal ureteric stricture, gross hydronephrosis, previous ureteral surgery and solitary kidney were excluded. After informed, written consent, all selected cases were divided in two groups by lottery method. In group A patients, tamsulosin was given while in group B patients, nifedipine was given. All patients were followed weekly by the researcher till 4 weeks and ultrasonography in both groups was done by the one consultant radiologist for evaluation of efficacy.
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