What is already known The zebrafish is a well-known tuberculosis disease model for qualitative efficacy screens in drug development. The information content and translational potential of qualitative assessments is low. What this study adds The isoniazid exposure-response relationship is quantified in zebrafish larvae using integrated experimental and computational innovation. With pharmacokinetic-pharmacodynamic modelling, quantitative translation of pharmacological findings from zebrafish larvae to humans is confirmed. Clinical significance Adding zebrafish larvae to the translational drug development pipeline could expedite development of anti-tuberculosis drugs.
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