Peracetic acid can
be used universally as a source of acetate and
an oxidant for the selective acetoxylation of C–H bonds in
compounds containing ortho-directing groups, catalyzed
by Pd(OAc)2. Compared to previous procedures, where persulfates
and PhI(OAc)2 were used, the new protocol provides significant
improvements in atom efficiency, product yield, substrate scope, cost,
scalability, and environmental impact.
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