A convenient method for the synthesis of oxyresveratrol catalyzed by palladium is described. 2,4-Dihydroxyiodobenzene underwent Heck reaction with acrylic acid, then decarboxylation, and further underwent Heck reaction with 3,5-dihydroxyiodobenzene, furnishing oxyresveratrol in a high yield. The title compound was characterized by MS and NMR. This synthetic method has several advantages such as less step processes, high yield, simple operations, and promises to be applied in industrial production.
The synthesis of two derivatives of isosorbide containing an amine group, 6-amino-6-deoxy- O-3-methyl-isosorbide and 6-amino- O-3-benzoyl-6-deoxy-isosorbide, has been achieved. These compounds provide scope for the introduction of additional groups via their amino functions and thereby can provide access to novel isosorbide derivatives that can be screened for biological activity.
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