Given the challenges in exploring lifelong therapy with little side effect for human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) cases, there is increasing interest in developing traditional Chinese medicine (TCM) treatments based on specific TCM syndrome. However, there are few objective and biological evidences for classification and diagnosis of HIV/AIDS TCM syndromes to date. In this study, iTRAQ-2DLC-MS/MS coupled with bioinformatics were firstly employed for comparative proteomic profiling of top popular TCM syndromes of HIV/AIDS: accumulation of heat-toxicity (AHT) and Yang deficiency of spleen and kidney (YDSK). It was found that for the two TCM syndromes, the identified differential expressed proteins (DEPs) as well as their biological function distributions and participation in signaling pathways were significantly different, providing biological evidence for the classification of HIV/AIDS TCM syndromes. Furthermore, the TCM syndrome-specific DEPs were confirmed as biomarkers based on western blot analyses, including FN1, GPX3, KRT10 for AHT and RBP4, ApoE, KNG1 for YDSK. These biomarkers also biologically linked with the specific TCM syndrome closely. Thus the clinical and biological basis for differentiation and diagnosis of HIV/AIDs TCM syndromes were provided for the first time, providing more opportunities for stable exertion and better application of TCM efficacy and superiority in HIV/AIDS treatment.
Background:
Chronic obstructive pulmonary disease (COPD) is a public threat, leading to progressive physical activity and poor quality of life. Although modern medicine has excellent achievement of COPD, the recurrence rate of stable COPD and the mortality of acute exacerbation COPD remain high. As one of the external therapy of traditional Chinese medicine, acupoint application has been treated COPD in China for a long time. Nevertheless, study evaluating the effect of acupoint application for COPD could not satisfy needs for clinic.
Method:
Randomized controlled trials meeting the inclusion criteria will be collected by the 2 reviewers. We choose the following electronic databases of Web of Science, Pub Med, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Wan Fang, Chinese Scientific Journals Database, and Chinese Biomedical Database as our retrieval tool. The retrieval time was from inception to March 2020. The key to evaluation criteria is total clinical efficacy rate and lung function will be measured. Secondary outcomes include assessment scales and adverse reactions. The studies extracted will be assessed. The merging analysis will be carried out by Review Manager Software.
Result:
A scientific evidence of efficacy and safety of acupoint application for COPD will be found.
Conclusion:
The evaluation of the efficacy and safety of acupoint application for COPD will be presented.
INPLASY registration number:
INPLASY202090023.
C hina has a large aging population, and tumorcarrying and senile patients are increasing along with their medical demand. However, China's medical resources are limited. Recently, experts have proposed a new concept called ''integrative palliative care'' (IPC) 1 that aims to improve efficacy of treatment and relieve pain. Similarly, Traditional Chinese Medicine (TCM) also emphasizes improving symptoms and relieving discomfort. It is believed that both approaches will be helpful for meeting increases in medical requirements of elderly patients in China. Similarities Between TCM and IPC Similarity of core ideas Thousands of years ago, the TCM classic ''Inner Canon of Huangdi'' proposed ''heaven and nature united.'' This concept of the harmony between man, community, and nature is similar to holism-recognition of the primacy of body/mind/spirit-and is the foundation of integrative medicine and palliative care. Similarity of understanding of human health TCM focuses on both wellness and quality of life in serious illness, which coincides with the goals of IPC. They both consider the ''whole person'' (mind, body, and spirit).
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